Questions raised by the Benelux CML Study Group: results from the randomized study with hydroxyurea alone versus hydroxyurea combined with low-dose interferon-alpha2b for chronic myeloid leukemia.
نویسندگان
چکیده
2. Davis GL, Esteban-Mur R, Rustgi V, Hoefs J, Gordon S, Trepo C, Shiffman M, Zeuzem S, Craxi A, Raffanel C, Reindollar R, Rizzetto M, International Hepatitis Interventional Therapy Group: Retreatment of relapser after interferon therapy for chronic hepatitis C: An international randomized controlled trial of interferon plus ribavirin VS interferon alone. Hepatology 26:247A, 1997 (abstr) 3. Ferri C, La Civita L, Zignego AL: Extrahepatic manifestations of hepatitis C virus infection. Ann Intern Med 125:344, 1996 (letter)
منابع مشابه
Randomized Study on Hydroxyurea Alone Versus Hydroxyurea Combined With Low-Dose Interferon-a2b for Chronic Myeloid Leukemia
Interferon-a (IFN-a) is considered the standard therapy for chronic myeloid leukemia (CML) patients not suitable for allogeneic stem cell transplantation. From 1987 through 1992, 195 patients in the Benelux with recent untreated CML were randomized between low-dose IFN-a2b (3 MIU, 5 days/wk) or hydroxyurea alone (control group). The white blood cell count had to be kept less than 10 3 109/L in ...
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The optimal dose of interferon-alfa (IFN) for chronic myeloid leukemia (CML) is unknown. Retrospective analyses suggest that low doses are as effective as high doses, with less toxicity and fewer patients abandoning the drug. The Dutch Hemato-Oncology Association (HOVON) and British Medical Research Council (MRC) cooperative groups jointly performed randomized trials in newly diagnosed CML pati...
متن کاملInterferon alfa versus chemotherapy for chronic myeloid leukemia: a meta-analysis of seven randomized trials: Chronic Myeloid Leukemia Trialists' Collaborative Group.
BACKGROUND Several randomized clinical trials in chronic myeloid leukemia (CML) have reported better patient survival with interferon alfa (IFN alpha) than with standard chemotherapeutic agents, such as busulfan or hydroxyurea. However, the size and persistence of this survival benefit is uncertain. Our aim was to assess these reliably, both overall and in particular patient subgroups. METHOD...
متن کاملRandomized comparison of busulfan and hydroxyurea in chronic myelogenous leukemia: prolongation of survival by hydroxyurea. The German CML Study Group.
In a randomized multicenter study the influence of hydroxyurea versus busulfan on the duration of the chronic phase and on survival of chronic myelogenous leukemia (CML) was determined. In addition cross resistance and adverse reactions of the drugs were analyzed. From July 1983 to January 1991, 441 CML patients were randomized to receive hydroxyurea or busulfan. Of these, 90.7% were Philadelph...
متن کاملRandomized Comparison of Interferon-a, Hydroxyurea, and Busulfan in Chronic Myeloid Leukemia: Response to Kantarjian and Talpaz and to Tura and Baccarani
We appreciate the letters by Kantarjian and Talpaz and by Tura and Baccarani regarding our report.’ Kantarjian and Talpaz compare their retrospective study on 274 interferon-a (R%)-treated chronic myeloid leukemia (CML) patients’ with the IFN arm of our randomized prospective study that compares I F N with hydroxyurea and busulfan. Although the quality of the group’s studies is acknowledged, it...
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عنوان ژورنال:
- Blood
دوره 92 8 شماره
صفحات -
تاریخ انتشار 1998